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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NUAK1
All Species:
25.76
Human Site:
S580
Identified Species:
43.59
UniProt:
O60285
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O60285
NP_055655.1
661
74305
S580
S
D
D
S
V
L
S
S
D
S
F
D
L
L
D
Chimpanzee
Pan troglodytes
XP_001161041
661
74289
S580
S
D
D
S
V
L
S
S
D
S
F
D
L
L
D
Rhesus Macaque
Macaca mulatta
XP_001098986
667
74748
S586
S
D
D
S
V
L
S
S
D
S
F
D
L
L
D
Dog
Lupus familis
XP_538417
666
74288
S585
S
D
D
S
V
L
S
S
D
S
F
D
L
L
D
Cat
Felis silvestris
Mouse
Mus musculus
Q641K5
658
73643
S581
S
D
D
S
V
L
S
S
D
S
F
D
L
L
E
Rat
Rattus norvegicus
Q66HE5
630
69934
S559
D
S
I
L
S
S
E
S
F
D
Q
L
D
L
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508265
661
73136
S580
S
D
D
S
I
L
S
S
D
S
F
D
L
L
D
Chicken
Gallus gallus
Q9IA88
798
88848
R572
P
V
S
F
Q
E
G
R
R
A
S
D
T
S
L
Frog
Xenopus laevis
NP_001088596
570
64876
E499
D
F
P
G
K
Y
R
E
R
A
R
G
K
T
R
Zebra Danio
Brachydanio rerio
Q6NSM8
1187
130949
T902
Y
R
P
P
P
Q
V
T
P
T
L
Q
G
L
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_649991
1427
153426
V1203
E
F
I
I
P
I
A
V
E
G
G
G
F
I
T
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q9TW45
1192
126331
S746
S
S
S
S
S
A
T
S
T
A
P
L
Q
K
S
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P92958
512
58671
G440
W
V
P
G
L
A
D
G
Q
N
T
M
V
N
N
Baker's Yeast
Sacchar. cerevisiae
P06782
633
72027
N559
I
G
N
K
T
N
T
N
E
K
I
P
D
L
M
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
97.9
91.7
N.A.
90.9
55.6
N.A.
84.2
26.1
48.5
23.5
N.A.
24.3
N.A.
22.4
N.A.
Protein Similarity:
100
99.8
98
94.4
N.A.
93.8
68
N.A.
88
42.8
61.4
36.2
N.A.
33.6
N.A.
35.8
N.A.
P-Site Identity:
100
100
100
100
N.A.
93.3
13.3
N.A.
93.3
6.6
0
6.6
N.A.
0
N.A.
20
N.A.
P-Site Similarity:
100
100
100
100
N.A.
100
13.3
N.A.
100
13.3
6.6
20
N.A.
26.6
N.A.
33.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
31.1
26.7
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
49.3
46.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
26.6
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
15
8
0
0
22
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
15
43
43
0
0
0
8
0
43
8
0
50
15
0
36
% D
% Glu:
8
0
0
0
0
8
8
8
15
0
0
0
0
0
8
% E
% Phe:
0
15
0
8
0
0
0
0
8
0
43
0
8
0
0
% F
% Gly:
0
8
0
15
0
0
8
8
0
8
8
15
8
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
8
0
15
8
8
8
0
0
0
0
8
0
0
8
0
% I
% Lys:
0
0
0
8
8
0
0
0
0
8
0
0
8
8
0
% K
% Leu:
0
0
0
8
8
43
0
0
0
0
8
15
43
65
15
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
8
% M
% Asn:
0
0
8
0
0
8
0
8
0
8
0
0
0
8
8
% N
% Pro:
8
0
22
8
15
0
0
0
8
0
8
8
0
0
8
% P
% Gln:
0
0
0
0
8
8
0
0
8
0
8
8
8
0
0
% Q
% Arg:
0
8
0
0
0
0
8
8
15
0
8
0
0
0
8
% R
% Ser:
50
15
15
50
15
8
43
58
0
43
8
0
0
8
8
% S
% Thr:
0
0
0
0
8
0
15
8
8
8
8
0
8
8
8
% T
% Val:
0
15
0
0
36
0
8
8
0
0
0
0
8
0
0
% V
% Trp:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
8
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _